Commonly reported side effects of doxorubicin include: severe nausea and vomiting, nausea and vomiting, and alopecia. Doxorubicin Liposome (Intravenous Route) Print. The rate of cardiomyopathy is dependent on its cumulative dose, with an incidence about 4% when the dose of doxorubicin is 500-550 mg/m², 18% when the dose is 551-600 mg/m² and 36% when the dose exceeds 600 mg/m². It is best to read this information with our general information about chemotherapy and the type of cancer you have.. Doxorubicin may cause heart problems that may lead to death. Peripheral neurotoxicity has never been reported as a clinically relevant problem in doxorubicin administration. Less common side effects include mouth sores, adverse effects on future fertility, irregular heartbeat; and leukemia, which may develop years after … Applies to doxorubicin: intravenous powder for solution, intravenous solutionAlong with its needed effects, doxorubicin may cause some unwanted effects. Your doctor will talk to you about this treatment and its possible side effects before you agree to have treatment. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. prednisone, methotrexate, dexamethasone, Arimidex, Armour Thyroid, Keytruda, fluorouracil, rituximab, Ibrance, Imbruvica. In some cases, drug therapy may be needed to prevent or relieve nausea and vomiting. Doxorubicin tissue extravasation has the potential to be catastrophic. Available for Android and iOS devices. 2006). It works by killing cancer cells. Use of haemopoietic growth factor (G-CSF, GM-CSF) may be considered. swelling in the feet and legs. Call your doctor for medical advice about side effects. Myocardial damage can occur with DOXOrubicin hydrochloride with incidences from 1% to 20% for cumulative doses from 300 to 500 mg/m(2) when DOXOrubicin hydrochloride is administered every 3 weeks. There are minor effects that are picked up on the electrocardiogram (EKG) and in most cases resolve wi… side pain. Doxorubicin (Intravenous Route) Print. There are several ways in … Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Doxorubicin Side Effects What should I watch for? During this period of time, Check with your doctor immediately if you notice the following side effects: Applies to doxorubicin: compounding powder, intravenous powder for injection, intravenous solution, Common (1% to 10%): Cardiomyopathy, decreased LVEF, ECG changes (e.g., sinus tachycardia, tachyarrhythmia, ventricular tachycardia, bradycardia, bundle branch block), congestive heart failure, Very rare (less than 0.01%): Pericarditis, myocarditis, Postmarketing reports: Cardiogenic shock, phlebosclerosis, phlebitis/thrombophlebitis, hot flashes, thromboembolism[Ref], Very common (10% or more): Leucopenia (60% to 80%), Common (1% to 10%): Bone marrow suppression, Uncommon (0.1% to 1%): Thrombocytopenia[Ref], Rare (less than 0.1%): Urticaria, exanthema, local erythematous reactions along the vein which was used for the injection, hyperpigmentation of skin and nails, onycholysis, Postmarketing reports: Oncolysis, rash, itching, photosensitivity, urticaria, acral erythema, palmar plantar erythrodysesthesia[Ref], Very common (10% or more): Nausea and vomiting (20% to 85%), stomatitis (up to 80%), diarrhea (12%), Uncommon (0.1% to 1%): Ulceration and necrosis of the colon, especially the cecum (in combination with cytarabine)[Ref], Frequency not reported: Extravasation, tissue necrosis[Ref], Rare (0.01% to 0.1%): Anaphylactic reactions[Ref], Rare (0.01% to 0.1%): Renal insufficiency[Ref], Postmarketing reports: Malaise, asthenia, fever, chills[Ref], Common (1% to 10%): Secondary malignancies[Ref], Postmarketing reports: Keratitis, lacrimation[Ref], Common (1% to 10%): Local reactions (chemical cystitis) may occur with intravesical treatment, Rare (less than 0.1%): Bladder contracture, Frequency not reported: Hyperuricemia, tumor lysis syndrome, Postmarketing reports: Increased alanine aminotransferase, increased aspartate aminotransferase[Ref], Frequency not reported: Bronchospasm, cough, epistaxis, pneumonia, nasopharyngitis, upper respiratory tract infection[Ref], Postmarketing reports: Peripheral sensory and motor neuropathy, seizures, coma[Ref]. Nausea and vomiting can be severe. Adriamycin PFS (doxorubicin)." SIDE EFFECTS: The table includes adverse events that presented during drug treatment but may not necessarily have a causal relationship with the drug. The most dangerous side effect of doxorubicin is dilated cardiomyopathy, leading to congestive heart failure. This is one of the main reasons that only trained personnel should handle doxorubicin. It should be used under the supervision of a qualified physician. … Advertising revenue supports our not-for-profit mission. Doxorubicin (Plain) is an anticancer agent which is used in the treatment of various cancers of blood, breast and female reproductive system. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. See also Warning section.Nausea, vomiting, diarrhea, and loss of appetite may occur. 2. Nausea and vomiting can be severe. Severe myelosuppression resulting in serious infection, septic shock, requirement for transfusions, hospitalization, and death may occur. Acute overdosage may increase the toxic effects of mucositis, leukopenia and thrombocytopenia. Information about indications was extracted from the indications and usage sections of the labels. Mayo Clinic does not endorse companies or products. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: After you stop using this medicine, it may still produce some side effects that need attention. Because clinical trials are conducted under very specific conditions, the adverse event ... pharmacological effects of doxorubicin doxorubicin metabolism increased by barbiturates via CYP3A4 induction : monitor therapy . The rate of cardiomyopathy is dependent on its cumulative dose, with an incidence about 4% when the dose of doxorubicin is 500–550 mg/m , 18% when the dose is 551–600 mg/m and 36% when the dose exceeds 600 mg/m . Check with your doctor or nurse immediately if any of the following side effects occur: Some side effects may occur that usually do not need medical attention. … This is not uncommon, as chemotherapy can affect healthy cells as well as cancer cells. Although not all of these side effects may occur, if they do occur they may need medical attention. Because doxorubicin attacks rapidly dividing cells it is also toxic to normal cells with high division rates: hair follicle cells, bone marrow cells, and intestinal cells. These side effects may go away during treatment as your body adjusts to the medicine. Description and Brand Names; Before Using; Proper Use; Precautions; Side Effects; Products and services. When to contact your team. Common side effects may include: nausea, vomiting; or hair loss. Treatment includes hospitalisation of the severely myelosuppressed patient, antimicrobials, platelet transfusions and symptomatic treatment of mucositis. It is well recognized that doxorubicin may cause damage to the heart in some individuals. stomach pain. Body aches/pains, headache, nausea, vomiting, constipation, diarrhea, stomach upset, and loss of appetite may occur. These side effects may go away during treatment as your body adjusts to the medicine. Extravasation, or leaking of a drug outside of a vein, of some chemotherapeutics can cause mild to moderate tissue irritation, but doxorubicin can cause tissue sloughing, necrosis, and wounds that can take months to heal and may require amputation. Its cytotoxic effect produced by intercalating with DNA causing breakdown of DNA strand which causes cancer cell apoptosis. Doxorubicin is a type of chemotherapy drug called an anthracycline. 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