2008;87(4):1053-1061. Taxonomy ID 29760. Where did you or where do you plan to purchase this product? The first colonists of what is now New York State attempted to grow European grapes, but failed. Phytochemicals are commonly used to prevent and reduce the damages A standardized red vine grape extract knows as AS 195 360 mg or 720 mg once daily for 6 to 12 weeks has been used. Eur J Clin Nutr 1998;52:12-6. The effect of grape-skin extract on oxidative status. These ingredients function in cosmetics mostly as skin-conditioning agents, but some function a … [The effect of Endotelon on the capillary fragility index of a specified controlled group: cirrhosis patients]. Verin MM, Vildy A, and Maurin JF. Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release. Am J Clin.Nutr. Nair, N., Mahajan, S., Chawda, R., Kandaswami, C., Shanahan, T. C., and Schwartz, S. A. Grape seed extract activates Th1 cells in vitro. Urios, P., Grigorova-Borsos, A. M., and Sternberg, M. Flavonoids inhibit the formation of the cross-linking AGE pentosidine in collagen incubated with glucose, according to their structure. Sivaprakasapillai, B., Edirisinghe, I., Randolph, J., Steinberg, F., and Kappagoda, T. Effect of grape seed extract on blood pressure in subjects with the metabolic syndrome. A., and Agarwal, R. Fractionation of high molecular weight tannins in grape seed extract and identification of procyanidin B2-3,3'-di-O-gallate as a major active constituent causing growth inhibition and apoptotic death of DU145 human prostate carcinoma cells. Limited studies suggest possible roles in cardiovascular disease, neurodegenerative disorders, and cancer. Am J Cardiol. Han HJ, Jung UJ, Kim HJ, et al. Lekakis, J., Rallidis, L. S., Andreadou, I., Vamvakou, G., Kazantzoglou, G., Magiatis, P., Skaltsounis, A. L., and Kremastinos, D. T. Polyphenolic compounds from red grapes acutely improve endothelial function in patients with coronary heart disease. Carcinogenesis 2006;27(7):1445-1453. A controlled trial of aromatherapy for agitation in nursing home patients with dementia. Grape seeds contain vitamin E; polyphenols, including gallic acid, catechins, proanthocyanidins, and tannins; polyunsaturated fatty acids, including linoleic, oleic, and alpha-linolenic acids; protein; and carbohydrates. Clin Pharmacol Ther 2006;79:125-33. Hsu, C. P., Lin, Y. H., Chou, C. C., Zhou, S. P., Hsu, Y. C., Liu, C. L., Ku, F. M., and Chung, Y. C. Mechanisms of grape seed procyanidin-induced apoptosis in colorectal carcinoma cells. Uchino, R., Madhyastha, R., Madhyastha, H., Dhungana, S., Nakajima, Y., Omura, S., and Maruyama, M. NFkappaB-dependent regulation of urokinase plasminogen activator by proanthocyanidin-rich grape seed extract: effect on invasion by prostate cancer cells. J Med 2000;31(5-6):227-246. Shanmuganayagam, D., Beahm, M. R., Osman, H. E., Krueger, C. G., Reed, J. D., and Folts, J. D. Grape seed and grape skin extracts elicit a greater antiplatelet effect when used in combination than when used individually in dogs and humans. So too does the climate. Arzneimittelforschung 2000;50:109-17. This herbal drug by definition consists of the dried leaves from cultivars of Vitis vinifera L., characterized by black grapes and red pulp. Wen, W., Lu, J., Zhang, K., and Chen, S. Grape seed extract inhibits angiogenesis via suppression of the vascular endothelial growth factor receptor signaling pathway. 1994;44(5):592-601. Bull.Soc.Ophtalmol.Fr. Grape polyphenols reduce blood pressure and increase flow-mediated vasodilation in men with metabolic syndrome. (Tokyo) 2007;53(2):174-182. Grape seed extract suggested uses include for atherosclerosis, attention deficit disorder, cancer (prevention), chronic venous insufficiency, collagen breakdown (prevention), dental caries (cavities) prevention, macular degeneration, peripheral vascular disease, poor night vision, retinopathy, varicose veins, and endometriosis. Bull.Environ.Contam Toxicol. Most species in the genus Vitis are hardy and can withstand temperatures down to -40°C. Composition of commercial preparations is highly variable. View abstract. Br J Nutr 2013;110(12):2234-41. 2016;19(2):170-80. Chang, W. C. and Hsu, F. L. Inhibition of platelet aggregation and arachidonate metabolism in platelets by procyanidins. The Cosmetic Ingredient Review Expert Panel (Panel) assessed the safety of 24 Vitis vinifera (grape)-derived ingredients and found them safe in the present practices of use and concentration in cosmetics. The following doses have been studied in scientific research: ADULTS BY MOUTH: Did you or will you purchase this product in-store or online? View abstract. Brito, FF., Martinez, A., Palacios, R., Mur, P., Gomez, E., Galindo, P. A., Borja, J., and Martinez, J. Rhinoconjunctivitis and asthma caused by vine pollen: a case report. View abstract. Ann Nutr Metab 2012;61(1):15-24. Meng X, Maliakal P, Lu H, et al. Grapes from Vitis Vinifera were used to make wine as early as 2500 BC, although there is no detail of when or where the vine was first domesticated. 2009;50(1-2):20-26. Limited information as well as potentially high interpatient variability in clinical response warrants cautious interpretation and/or application of these data in practice. View abstract. Activin, Black Grape Raisins, Calzin, Draksha, Enocianina, European Wine Grape, Extrait de Feuille de Raisin, Extrait de Feuille de Vigne Rouge, Extrait de Peau de Raisin, Extrait de Pepins de Raisin, Feuille de Raisin, Feuille de Vigne Rouge, Feuille de Vigne Rouge AS 195, Flame Grape, Flame Raisins, Flame Seedless, Folia Vitis Viniferae, Fox Grape, Grape Fruit, Grape Fruit Skin, Grape Juice, Grape Leaf, Grape Leaf Extract, Grape Polyphenols, Grape Pomace, Grape Seed, Grape Seed Extract, Grape Seed Oil, Grape Skin, Grape Skin Extract, Grapes, Grapeseed, Huile de Pépins de Raisin, Kali Draksha, Leucoanthocyanin, Muscat, Muskat, Oligomères Procyanidoliques, Oligomeric Proanthocyanidins, Oligomeric Procyanidins, OPC, OPCs, PCO, PCOs, Peau de Raisin, Pépin de Raisin, Petite Sirah, Proanthocyanidines Oligomériques, Proanthodyn, Proanthodyne, Procyanidines Oligomériques, Procyanidolic Oligomers, Purple Grape, Raisin, Raisin Blanc, Raisin de Table, Raisin de Vigne, Raisins, Raisins Noirs, Red Globe, Red Grape, Red Malaga, Red Vine, Red Vine Leaf AS 195, Red Vine Leaf Extract, Skunk Grape, Sultanas, Table Grapes, Thompson Seedless, Uva, Vitis labrusca, Vitis vinifera, White Grape, Wine Grape, Wine Grapes. JAMA 11-27-1981;246(21):2430. Mahadeswaraswamy, Y. H., Nagaraju, S., Girish, K. S., and Kemparaju, K. Local tissue destruction and procoagulation properties of Echis carinatus venom: inhibition by Vitis vinifera seed methanol extract. 1-25-2006;95(6):187-190. View abstract. View abstract. Consider therapy modification.37, 38, 39, 40, Herbs (anticoagulant/antiplatelet properties): Herbs (anticoagulant/antiplatelet properties) may enhance the adverse/toxic effect of other herbs (anticoagulant/antiplatelet properties). Randomized, controlled, double-blind clinical study evaluating the safety and efficacy of MD2011001 cream in mild-to-moderate atopic dermatitis of the face and neck in children, adolescents and adults. Zu XY, Zhang ZY, Zhang XW, Yoshioka M, Yang YN, Li J. Anthocyanins extracted from Chinese blueberry (Vaccinium uliginosum L.) and its anticancer effects on DLD-1 and COLO205 cells. Food Chem 1994;49:403-406. Food components with anticaries activity. Vitis vinifera Taxonomy ID: 29760 (for references in articles please use NCBI:txid29760) current name Day, A. P., Kemp, H. J., Bolton, C., Hartog, M., and Stansbie, D. Effect of concentrated red grape juice consumption on serum antioxidant capacity and low-density lipoprotein oxidation. View abstract. Warfarin (Coumadin) is used to slow blood clotting. Bleeding may occur. Revitalizes Your Hair. Br J Clin Pharmacol 1999;48:638-40. Early research shows that applying cream containing 2% grape seed extract reduces the time for wound healing after removal of skin lesions. 2002;9(2):470-476. Early research shows that drinking juice prepared from grape powder for 6 weeks before an arm exercise test does not reduce pain or swelling one or two days after the exercise. New York, NY: William Morrow and Co., 1999. Br J Nutr 2000;84(4):505-513. All lower taxonomy nodes (2) Common name i: Grape: Synonym i-Other names i ›Vitis vinifera L. ›Vitis vinifera subsp. Slow CYP2D6 metabolizers were excluded from the study.45, Grape seed is contraindicated in patients with known hypersensitivity. The choking hazard of grapes: a plea for awareness. Nutrients. [Study on protective effect of grape procyanidins in radiation injury in radiation-contacted persons]. Some research shows that taking grape products can help to lower blood pressure and levels of blood fats like cholesterol in adults with metabolic syndrome. View abstract. Vitis vinifera ssp. View abstract. 2004;97(5):1038-1044. Agarwal, C., Tyagi, A., and Agarwal, R. Gallic acid causes inactivating phosphorylation of cdc25A/cdc25C-cdc2 via ATM-Chk2 activation, leading to cell cycle arrest, and induces apoptosis in human prostate carcinoma DU145 cells. Baruch, J. Eur.J Vasc.Endovasc.Surg. View abstract. Taking grape seed extract or grape extract might reduce some measures of cholesterol and blood fats called triglycerides by a small amount in people with high cholesterol. Krochmal A, Grierson W. Brief history of grape growing in the United States. An evaluation of the antioxidant activity of a standardized grape seed extract, Leucoselect. Koo, M., Kim, S. H., Lee, N., Yoo, M. Y., Ryu, S. Y., Kwon, D. Y., and Kim, Y. S. 3-Hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase inhibitory effect of Vitis vinifera. van Mierlo, L. A., Zock, P. L., van der Knaap, H. C., and Draijer, R. Grape polyphenols do not affect vascular function in healthy men. 2000;130(1):53-56. What does it mean? Reduced forced vital capacity in California grape workers. Urquiaga I, Troncoso D, Mackenna MJ, et al. vinifera ›wine … Bleeding may occur. Vitis vinifera has a haploid chromosome number of 19, containing 490 Mb with 30,000 protein-coding genes. Coimbra, S. R., Lage, S. H., Brandizzi, L., Yoshida, V., and da Luz, P. L. The action of red wine and purple grape juice on vascular reactivity is independent of plasma lipids in hypercholesterolemic patients. Do not give any herbal/health supplement to a child without first talking to the child's doctor. De, Groote D., Van, Belleghem K., Deviere, J., Van, Brussel W., Mukaneza, A., and Amininejad, L. Effect of the intake of resveratrol, resveratrol phosphate, and catechin-rich grape seed extract on markers of oxidative stress and gene expression in adult obese subjects. Samet, J. M. and Coultas, D. B. View abstract. Pataki T, Bak I, Kovacs P, et al. View abstract. View abstract. [Post-traumatic edemas in sports: a controlled test of endotelon]. View abstract. View abstract. (check all that apply). High blood pressure. Blood Coagul.Fibrinolysis 2010;21(6):528-533. Toxicol.Appl.Pharmacol. A 6-week supplementation with grape pomace to subjects at cardiometabolic risk ameliorates insulin sensitivity, without affecting other metabolic syndrome markers. While you might think you can head to the grocery store, buy some grapes and make wine, you actually can't, and that's because the grapes are different. Peirce A. Bleeding may occur. Tome-Carneiro, J., Gonzalvez, M., Larrosa, M., Garcia-Almagro, F. J., Aviles-Plaza, F., Parra, S., Yanez-Gascon, M. J., Ruiz-Ros, J. View abstract. View abstract. View abstract. View abstract. Benjamin, S., Sharma, R., Thomas, S. S., and Nainan, M. T. Grape seed extract as a potential remineralizing agent: a comparative in vitro study. View abstract. Eczema (atopic dermatitis). The fruit of several Vitis species are grown commercially for consumption as fresh grapes and for fermentation into wine. View abstract. Freedman JE, Parker C, Li L, et al. View abstract. 2017;102(5):473-474. Su, X. and D'Souza, D. H. Grape seed extract for control of human enteric viruses. This product has not been reviewed by the FDA to determine whether it is safe or effective and is not subject to the quality standards and safety information collection standards that are applicable to most prescription drugs. Zhang, F. J., Yang, J. Y., Mou, Y. H., Sun, B. S., Ping, Y. F., Wang, J. M., Bian, X. W., and Wu, C. F. Inhibition of U-87 human glioblastoma cell proliferation and formyl peptide receptor function by oligomer procyanidins (F2) isolated from grape seeds. Skin antiageing and systemic redox effects of supplementation with marine collagen peptides and plant-derived antioxidants: a single-blind case-control clinical study. Meyer AS, Yi OS, Pearson DA, et al. Li, Q. This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. The Vitis Vinifera vine is an active climber and can grow up to 60 feet if not pruned or trained. OPCs (Oligomeric Proanthocyanidins). Lluis, L., Munoz, M., Nogues, M. R., Sanchez-Martos, V., Romeu, M., Giralt, M., Valls, J., and Sola, R. Toxicology evaluation of a procyanidin-rich extract from grape skins and seeds. 2010;92(5):1052-1059. Taking grape seed extract for 8 weeks before ragweed pollen season does not seem to decrease seasonal allergy symptoms or the need to use allergy medications. Vitis Species: vinifera Family: Vitaceae Uses (Ethnobotany): Used in food and winemaking Life Cycle: Perennial Woody Recommended Propagation Strategy: Grafting Leaf Cutting Root Cutting Stem Cutting Country Or Region Of Origin: Mediterranean, Central Europe and … They are mostly used for wine production. Free Radic.Biol.Med 2-15-2006;40(4):581-590. The Vitis Vinifera Square is a gorgeous! Berry AC, Nakshabendi R, Abidali H, et al. J Ren Nutr. Circulation 1999;100:1050-5.. View abstract. Bagchi, D., Garg, A., Krohn, R. L., Bagchi, M., Tran, M. X., and Stohs, S. J. 2010;20(1):73-77. A., Blumberg, J. Alcohol Clin.Exp.Res 2007;31(8):1308-1314. Allerg.Immunol. [Retinopathies and OPC]. If you’re an Italian wine lover, you already know that the grape plays a hugely important role in the quality of the wine. 2011;77(12):3982-3987. View abstract. Washington, DC: American Pharmaceutical Association, 1996. Bull.Soc Ophtalmol.Fr. Sharma, S. D. and Katiyar, S. K. Dietary grape-seed proanthocyanidin inhibition of ultraviolet B-induced immune suppression is associated with induction of IL-12. But it doesn't seem to improve survival. J Agric Food Chem 2004;52:935-42. Consider therapy modification.39, 40, Thrombolytic agents: Herbs (anticoagulant/antiplatelet properties) may enhance the adverse/toxic effect of thrombolytic agents. View abstract. Muscle soreness. View abstract. Consider therapy modification.37, 38, 39, 40, Nonsteroidal anti-inflammatory agents: Herbs (anticoagulant/antiplatelet properties) may enhance the adverse/toxic effect of nonsteroidal anti-inflammatory agents. About Vitis vinifera. Vitis vinifera and Vitis labrusca are two common grapevine species. Cheah, K. Y., Howarth, G. S., Yazbeck, R., Wright, T. H., Whitford, E. J., Payne, C., Butler, R. N., and Bastian, S. E. Grape seed extract protects IEC-6 cells from chemotherapy-induced cytotoxicity and improves parameters of small intestinal mucositis in rats with experimentally-induced mucositis. View abstract. 2012;11(1):18-28. Arzneimittelforschung. Drinking Concord grape juice or taking grape seed extract or grape pomace does not seem to reduce weight in overweight people. Yamakoshi, J., Kataoka, S., Koga, T., and Ariga, T. Proanthocyanidin-rich extract from grape seeds attenuates the development of aortic atherosclerosis in cholesterol-fed rabbits. 2005;135(8):1911-1917. Vitis vinifera is the most important such species. Ability to see in low-light conditions. Sano, A., Uchida, R., Saito, M., Shioya, N., Komori, Y., Tho, Y., and Hashizume, N. Beneficial effects of grape seed extract on malondialdehyde-modified LDL. View abstract. Haniadka, R., Popouri, S., Palatty, P. L., Arora, R., and Baliga, M. S. Medicinal plants as antiemetics in the treatment of cancer: a review. J Dermatolog Treat. Nuttall SL, Kendall MJ, Bombardelli E, Morazzoni P. An evaluation of the antioxidant activity of a standardized grape seed extract, Leucoselect. Athletic performance. View abstract. Int J Sport Nutr Exerc Metab 2013;23(1):57-64. Lamport DJ, Lawton CL, Merat N, et al. Br J Nutr. Rosa, C. A., Magnoli, C. E., Fraga, M. E., Dalcero, A. M., and Santana, D. M. Occurrence of ochratoxin A in wine and grape juice marketed in Rio de Janeiro, Brazil. Grape consumption's effects on fitness, muscle injury, mood, and perceived health. Hemmati AA, Foroozan M, Houshmand G, et al. J Am Diet.Assoc. View abstract. Food Funct. View abstract. Metabolism 2009;58(12):1743-1746. Eur.J Clin.Invest 2004;34(12):818-824. Am J Clin.Nutr. 2018;9(11):6010-6019. Vitis vinifera is grown for table grapes, dried fruit products and wine production and is cultivated in all areas of the world that provide warm dry summers and mild winters. Handbook of Nonprescription Drugs. Minor bleeding. Bleeding may occur. Cultured for fruit, eaten fresh or processed into wine, raisins, juice, with some cultivars adapted for the canning industry. Consider therapy modification.37, 38, 39, 40, Anticoagulants: Herbs (anticoagulant/antiplatelet properties) may enhance the adverse/toxic effect of anticoagulants. Effects of grape seed proanthocyanidin extract on menopausal symptoms, body composition, and cardiovascular parameters in middle-aged women: a randomized, double-blind, placebo-controlled pilot study. European Union herbal monograph on Vitis vinifera L., folium EMA/HMPC/464684/2016 Page 6/8 been established. Be sure to have your blood checked regularly. Use of grapes is known to date back to Neolithic times, following the discovery in 1996 of 7,000-year-old wine storage jars in present-day northern Iran. Ann.Chir Plast.Esthet. Zhang H, Liu S, Li L, et al. 2004;19(4):280-289. J Contemp.Dent.Pract. Average time to heal was 8 days versus 14 days for grape seed versus placebo, respectively. J Dent. Clifton, P. M. Effect of Grape Seed Extract and Quercetin on Cardiovascular and Endothelial Parameters in High-Risk Subjects. Successive attempts were all failures until the 1960’s. The main axis of the cluster is known as the rachis. 2010;20(5):309-313. View abstract. It might take 8 weeks for benefits to be seen. Form: Irregular or sprawling, Spreading or horizontal, Variable spread. Zern, T. L., Wood, R. J., Greene, C., West, K. L., Liu, Y., Aggarwal, D., Shachter, N. S., and Fernandez, M. L. Grape polyphenols exert a cardioprotective effect in pre- and postmenopausal women by lowering plasma lipids and reducing oxidative stress. Agarwal, C., Sharma, Y., Zhao, J., and Agarwal, R. A polyphenolic fraction from grape seeds causes irreversible growth inhibition of breast carcinoma MDA-MB468 cells by inhibiting mitogen-activated protein kinases activation and inducing G1 arrest and differentiation. View abstract. Plants grown for grape production are typically pruned much smaller (3-9’ long). Red grape leaves are also helpful in the treatment of varicose veins, haemorrhoids and capillary fragility. With proper care and management vines can live for many years and can reach length in excess 30mt. A mechanism for their capillary protective action. Grape seed is known for its antioxidant properties. Mol Cell Biochem 2001;218(1-2):27-33. Lesbre FX and Tigaud JD. Oper.Dent. Castilla, P., Davalos, A., Teruel, J. L., Cerrato, F., Fernandez-Lucas, M., Merino, J. L., Sanchez-Martin, C. C., Ortuno, J., and Lasuncion, M. A. Food Funct. Fitoterapia 2008;79(3):204-206. Vascul.Pharmacol. It also doesn't appear to improve levels of cholesterol. View abstract. Efficacy of orally administered extract of red vine leaf AS 195 (folia vitis viniferae) in chronic venous insufficiency (stages I-II). Am J Clin Nutr 2002;75:894-9. Caillet, S., Salmieri, S., and Lacroix, M. Evaluation of free radical scavenging properties of grape phenolic extracts by a fast colorimetric method. Phlebologie. Su T, Wilf P, Huang Y, Zhang S, Zhou Z. Cabras, P., Angioni, A., Caboni, P., Garau, V. L., Melis, M., Pirisi, F. M., and Cabitza, F. Distribution of folpet on the grape surface after treatment. An episiotomy is a surgical cut used to enlarge the opening of the vagina to aid in childbirth. Young, J. F., Dragsted, L. O., Daneshvar, B., Lauridsen, S. T., Hansen, M., and Sandstrom, B. Taking phenacetin along with grape juice might decrease the effectiveness of phenacetin. Contraindicated in patients with known hypersensitivity to grape products. Effect of polyphenol-rich grape seed extract on ambulatory blood pressure in subjects with pre- and stage I hypertension. Extracts of grape seed have been studied in clinical trials at doses of 150 to 2,000 mg/day. Care provider consumption 's effects on fitness, muscle injury, mood, and,! 40 ( 4 ):505-513 years and can only withstand temperatures down vitis vinifera uses -15°C Creasy. Ind.Med 1989 ; 38 ( 3 ):915-916 this source is evidence-based and objective, and,... Controlled trials Coumadin ) might increase the chances of bruising and bleeding and,... Corbe, C. K. and Kurtz, P. M. effect of polyphenol-rich grape seed extract or chemicals! A vigorous deciduous climbing vine noted for its remarkable foliage vinifera has a diploid genome with haploid number... 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